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Research Article

CpG-Methylation Regulates a Class of Epstein-Barr Virus Promoters

  • Martin Bergbauer,

    Affiliation: Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • Markus Kalla,

    Affiliation: Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • Anne Schmeinck,

    Affiliation: Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • Christine Göbel,

    Affiliation: Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • Ulrich Rothbauer,

    Affiliation: Biocenter at the Department of Biology II, Ludwig-Maximilians University Munich, Martinsried, Germany

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  • Sebastian Eck,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anna Benet-Pagès,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Tim M. Strom,

    Affiliation: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Wolfgang Hammerschmidt mail

    hammerschmidt@helmholtz-muenchen.de

    Affiliation: Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.ppat.1001114

About the Authors

Martin Bergbauer, Markus Kalla, Anne Schmeinck, Christine Göbel, Wolfgang Hammerschmidt
Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
Ulrich Rothbauer
Biocenter at the Department of Biology II, Ludwig-Maximilians University Munich, Martinsried, Germany
Sebastian Eck, Anna Benet-Pagès, Tim M. Strom
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

Corresponding Author

Email: hammerschmidt@helmholtz-muenchen.de

Competing Interests

U.R. is one of the founders and shareholders of ChromoTek, which is developing GFP-specific nanobodies for in vitro and in vivo applications used in this manuscript.

Author Contributions

Conceived and designed the experiments: MB MK WH. Performed the experiments: MB MK AS CG ABP. Analyzed the data: MB AS SE TMS WH. Contributed reagents/materials/analysis tools: UR SE. Wrote the paper: WH.