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Research Article

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

  • Asuka Nanbo,

    Affiliation: Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    Current address: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

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  • Masaki Imai,

    Affiliation: Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Shinji Watanabe,

    Affiliation: ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan

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  • Takeshi Noda,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Kei Takahashi,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Gabriele Neumann,

    Affiliation: Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Peter Halfmann,

    Affiliation: Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Yoshihiro Kawaoka mail

    kawaokay@svm.vetmed.wisc.edu

    Affiliations: Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan, Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.ppat.1001121

About the Authors

Asuka Nanbo, Masaki Imai, Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka
Influenza Research Institute, Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Shinji Watanabe, Yoshihiro Kawaoka
ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan
Takeshi Noda, Kei Takahashi, Yoshihiro Kawaoka
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan
Yoshihiro Kawaoka
International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

Corresponding Author

Email: kawaokay@svm.vetmed.wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AN YK. Performed the experiments: AN MI SW. Analyzed the data: AN SW GN YK. Contributed reagents/materials/analysis tools: MI SW TN KT PH YK. Wrote the paper: AN GN.