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Research Article

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

  • Markus Schrettl,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Nicola Beckmann,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • John Varga,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America, and The George Washington University School of Medicine, Department of Biochemistry and Molecular Biology, Washington, D.C., United States of America

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  • Thorsten Heinekamp,

    Affiliation: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Ilse D. Jacobsen,

    Affiliation: Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Christoph Jöchl,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Tarek A. Moussa,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Shaohua Wang,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Fabio Gsaller,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Michael Blatzer,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Ernst R. Werner,

    Affiliation: Division of Biological Chemistry/Biocenter, Medical University Innsbruck, Innsbruck, Austria

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  • William C. Niermann,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America, and The George Washington University School of Medicine, Department of Biochemistry and Molecular Biology, Washington, D.C., United States of America

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  • Axel A. Brakhage,

    Affiliation: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Hubertus Haas mail

    hubertus.haas@i-med.ac.at

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Published: September 30, 2010
  • DOI: 10.1371/journal.ppat.1001124

About the Authors

Markus Schrettl, Nicola Beckmann, Christoph Jöchl, Tarek A. Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Hubertus Haas
Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria
John Varga, William C. Niermann
J. Craig Venter Institute, Rockville, Maryland, United States of America, and The George Washington University School of Medicine, Department of Biochemistry and Molecular Biology, Washington, D.C., United States of America
Thorsten Heinekamp, Axel A. Brakhage
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany
Ilse D. Jacobsen
Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany
Ernst R. Werner
Division of Biological Chemistry/Biocenter, Medical University Innsbruck, Innsbruck, Austria

Corresponding Author

Email: hubertus.haas@i-med.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS NB JV TH IDJ CJ TAM SW FG MB ERW WCN AAB HH. Performed the experiments: MS NB JV TH IDJ CJ TAM SW FG MB ERW. Analyzed the data: MS NB JV TH IDJ CJ TAM SW FG MB ERW WCN AAB HH. Contributed reagents/materials/analysis tools: ERW WCN AAB HH. Wrote the paper: HH.