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Research Article

Pathogenic Bacteria Target NEDD8-Conjugated Cullins to Hijack Host-Cell Signaling Pathways

  • Grégory Jubelin equal contributor,

    equal contributor Contributed equally to this work with: Grégory Jubelin, Frédéric Taieb

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Frédéric Taieb equal contributor,

    equal contributor Contributed equally to this work with: Grégory Jubelin, Frédéric Taieb

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • David M. Duda,

    Affiliation: Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Department of Structural Biology, Memphis, Tennessee, United States of America

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  • Yun Hsu,

    Affiliation: Laboratory of Structural Microbiology, Rockefeller University, New York, New York, United States of America

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  • Ascel Samba-Louaka,

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Rika Nobe,

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Marie Penary,

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Claude Watrin,

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Jean-Philippe Nougayrède,

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France

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  • Brenda A. Schulman,

    Affiliation: Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Department of Structural Biology, Memphis, Tennessee, United States of America

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  • C. Erec Stebbins mail,

    stebbins@rockefeller.edu (CES); e.oswald@envt.fr (EO)

    Affiliation: Laboratory of Structural Microbiology, Rockefeller University, New York, New York, United States of America

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  • Eric Oswald mail

    stebbins@rockefeller.edu (CES); e.oswald@envt.fr (EO)

    Affiliations: INRA, UMR 1225, Toulouse, France, Université de Toulouse; ENVT; UMR 1225; Toulouse, France, Université de Toulouse; UPS; Faculté de Médecine; Toulouse, France, CHU de Toulouse; Institut Fédératif de Biologie; Laboratoire de Bactériologie-Hygiène; Toulouse, France

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  • Published: September 30, 2010
  • DOI: 10.1371/journal.ppat.1001128

About the Authors

Grégory Jubelin, Frédéric Taieb, Ascel Samba-Louaka, Rika Nobe, Marie Penary, Claude Watrin, Jean-Philippe Nougayrède, Eric Oswald
INRA, UMR 1225, Toulouse, France
Grégory Jubelin, Frédéric Taieb, Ascel Samba-Louaka, Rika Nobe, Marie Penary, Claude Watrin, Jean-Philippe Nougayrède, Eric Oswald
Université de Toulouse; ENVT; UMR 1225; Toulouse, France
David M. Duda, Brenda A. Schulman
Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Department of Structural Biology, Memphis, Tennessee, United States of America
Yun Hsu, C. Erec Stebbins
Laboratory of Structural Microbiology, Rockefeller University, New York, New York, United States of America
Eric Oswald
Université de Toulouse; UPS; Faculté de Médecine; Toulouse, France
Eric Oswald
CHU de Toulouse; Institut Fédératif de Biologie; Laboratoire de Bactériologie-Hygiène; Toulouse, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJ FT DMD YH ASL RN JPN BAS CES EO. Performed the experiments: GJ FT DMD YH ASL RN MP CW JPN. Analyzed the data: GJ FT DMD YH ASL JPN BAS CES EO. Wrote the paper: GJ FT DMD JPN BAS CES EO.