Advertisement
Research Article

Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

  • Christina M. Carlson equal contributor,

    equal contributor Contributed equally to this work with: Christina M. Carlson, Elizabeth A. Turpin

    Affiliation: Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Elizabeth A. Turpin equal contributor,

    equal contributor Contributed equally to this work with: Christina M. Carlson, Elizabeth A. Turpin

    Affiliation: Pfizer Inc., Department of Viral Vaccines, Research Triangle Park, North Carolina, United States of America

    X
  • Lindsey A. Moser,

    Affiliation: Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Kevin B. O'Brien,

    Affiliations: Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Troy D. Cline,

    Affiliation: Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Jeremy C. Jones,

    Affiliation: Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Terrence M. Tumpey,

    Affiliation: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Jacqueline M. Katz,

    Affiliation: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Laura A. Kelley,

    Affiliation: Biosciences Research Laboratory, USDA Agricultural Research Station, Fargo, North Dakota, United States of America

    X
  • Jack Gauldie,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

    X
  • Stacey Schultz-Cherry mail

    stacey.schultz-cherry@stjude.org

    Affiliation: Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Published: October 07, 2010
  • DOI: 10.1371/journal.ppat.1001136

About the Authors

Christina M. Carlson, Lindsey A. Moser, Kevin B. O'Brien
Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America
Elizabeth A. Turpin
Pfizer Inc., Department of Viral Vaccines, Research Triangle Park, North Carolina, United States of America
Kevin B. O'Brien, Troy D. Cline, Jeremy C. Jones, Stacey Schultz-Cherry
Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Terrence M. Tumpey, Jacqueline M. Katz
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Laura A. Kelley
Biosciences Research Laboratory, USDA Agricultural Research Station, Fargo, North Dakota, United States of America
Jack Gauldie
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: stacey.schultz-cherry@stjude.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMC EAT LAM KBO TDC TMT JMK SSC. Performed the experiments: CMC EAT LAM KBO TDC JCJ TMT LAK SSC. Analyzed the data: CMC EAT LAM TDC JCJ TMT JMK SSC. Contributed reagents/materials/analysis tools: JG SSC. Wrote the paper: EAT LAM SSC.