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Research Article

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

  • Abhisek Mukherjee,

    Affiliations: Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Diego Morales-Scheihing,

    Affiliation: Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America

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  • Dennisse Gonzalez-Romero,

    Affiliations: Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Kristi Green,

    Affiliation: Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Giulio Taglialatela,

    Affiliation: Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Claudio Soto mail

    Claudio.Soto@uth.tmc.edu

    Affiliations: Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: October 07, 2010
  • DOI: 10.1371/journal.ppat.1001138

About the Authors

Abhisek Mukherjee, Diego Morales-Scheihing, Dennisse Gonzalez-Romero, Claudio Soto
Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America
Abhisek Mukherjee, Dennisse Gonzalez-Romero, Kristi Green, Claudio Soto
Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America
Giulio Taglialatela, Claudio Soto
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America

Corresponding Author

Email: Claudio.Soto@uth.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM GT CS. Performed the experiments: AM DMS DGR KG. Analyzed the data: AM DMS GT CS. Wrote the paper: CS.