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Research Article

Viral Replication Rate Regulates Clinical Outcome and CD8 T Cell Responses during Highly Pathogenic H5N1 Influenza Virus Infection in Mice

  • Yasuko Hatta equal contributor,

    equal contributor Contributed equally to this work with: Yasuko Hatta, Karen Hershberger

    Affiliations: Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Karen Hershberger equal contributor,

    equal contributor Contributed equally to this work with: Yasuko Hatta, Karen Hershberger

    Affiliations: Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Kyoko Shinya,

    Affiliation: Division of Zoonosis, Department of Microbiology and Infectious Disease, Graduate School of Medicine, Kobe University, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan

    X
  • Sean C. Proll,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Richard R. Dubielzig,

    Affiliation: Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Masato Hatta,

    Affiliations: Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Michael G. Katze,

    Affiliation: Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Yoshihiro Kawaoka mail,

    sureshm@svm.vetmed.wisc.edu (MS); kawaokay@svm.vetmed.wisc.edu (YK)

    Affiliations: Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    X
  • M. Suresh mail

    sureshm@svm.vetmed.wisc.edu (MS); kawaokay@svm.vetmed.wisc.edu (YK)

    Affiliations: Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Published: October 07, 2010
  • DOI: 10.1371/journal.ppat.1001139

About the Authors

Yasuko Hatta, Karen Hershberger, Masato Hatta, Yoshihiro Kawaoka, M. Suresh
Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Yasuko Hatta, Karen Hershberger, Richard R. Dubielzig, Masato Hatta, Yoshihiro Kawaoka, M. Suresh
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Kyoko Shinya
Division of Zoonosis, Department of Microbiology and Infectious Disease, Graduate School of Medicine, Kobe University, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan
Sean C. Proll, Michael G. Katze
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America
Yoshihiro Kawaoka
Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YH KH YK MS. Performed the experiments: YH KH KS SCP MH. Analyzed the data: YH KH KS SCP RRD MH MGK YK MS. Contributed reagents/materials/analysis tools: MGK. Wrote the paper: YH YK MS.