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Research Article

Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1

  • Malte Bachmann equal contributor,

    equal contributor Contributed equally to this work with: Malte Bachmann, Katharina Horn

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Katharina Horn equal contributor,

    equal contributor Contributed equally to this work with: Malte Bachmann, Katharina Horn

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Ina Rudloff,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Itamar Goren,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Martin Holdener,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Urs Christen,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Nicole Darsow,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Klaus-Peter Hunfeld,

    Affiliations: Institute of Medical Microbiology and Infection Control, University Hospital Goethe University Frankfurt, Frankfurt, Germany, Institute for Laboratory Medicine, North West Medical Centre, Frankfurt, Germany

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  • Ulrike Koehl,

    Affiliation: Pediatric Hematology and Oncology, University Hospital Goethe-University Frankfurt, Frankfurt, Germany

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  • Peter Kind,

    Affiliation: Dermatohistological Laboratory Offenbach, Offenbach, Germany

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  • Josef Pfeilschifter,

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Peter Kraiczy,

    Affiliation: Institute of Medical Microbiology and Infection Control, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Heiko Mühl mail

    H.Muehl@em.uni-frankfurt.de

    Affiliation: pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany

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  • Published: October 14, 2010
  • DOI: 10.1371/journal.ppat.1001144

About the Authors

Malte Bachmann, Katharina Horn, Ina Rudloff, Itamar Goren, Martin Holdener, Urs Christen, Nicole Darsow, Josef Pfeilschifter, Heiko Mühl
pharmazentrum frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt, Germany
Klaus-Peter Hunfeld, Peter Kraiczy
Institute of Medical Microbiology and Infection Control, University Hospital Goethe University Frankfurt, Frankfurt, Germany
Klaus-Peter Hunfeld
Institute for Laboratory Medicine, North West Medical Centre, Frankfurt, Germany
Ulrike Koehl
Pediatric Hematology and Oncology, University Hospital Goethe-University Frankfurt, Frankfurt, Germany
Peter Kind
Dermatohistological Laboratory Offenbach, Offenbach, Germany

Corresponding Author

Email: H.Muehl@em.uni-frankfurt.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M. Bachmann, H. Mühl. Performed the experiments: M. Bachmann, K. Horn, I. Rudloff, I. Goren, M. Holdener, N. Darsow, U. Koehl. Analyzed the data: M. Bachmann, K. Horn, I. Rudloff, I. Goren, M. Holdener, U. Christen, K-P. Hunsfeld, U. Koehl, P. Kraiczy, H. Mühl. Contributed reagents/materials/analysis tools: U. Christen, P. Kind, J. Pfeilschifter, P. Kraiczy. Wrote the paper: H. Mühl.