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Research Article

Mycobacterium leprae Phenolglycolipid-1 Expressed by Engineered M. bovis BCG Modulates Early Interaction with Human Phagocytes

  • Guillaume Tabouret,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: INRA UMR 1225, IHAP, Ecole Nationale Vétérinaire, Toulouse, France

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  • Catherine Astarie-Dequeker,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Caroline Demangel,

    Affiliation: Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Wladimir Malaga,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Patricia Constant,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Aurélie Ray,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Nadine Honoré,

    Affiliation: Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Nana Fatimath Bello,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Esther Perez,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: Diseases of the Developing World (DDW), GlaxoSmithKline I+D, Tres Cantos, Madrid, Spain

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  • Mamadou Daffé,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Christophe Guilhot mail

    Christophe.Guilhot@ipbs.fr

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Published: October 21, 2010
  • DOI: 10.1371/journal.ppat.1001159

About the Authors

Guillaume Tabouret, Catherine Astarie-Dequeker, Wladimir Malaga, Patricia Constant, Aurélie Ray, Nana Fatimath Bello, Esther Perez, Mamadou Daffé, Christophe Guilhot
CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
Guillaume Tabouret, Catherine Astarie-Dequeker, Wladimir Malaga, Patricia Constant, Aurélie Ray, Nana Fatimath Bello, Esther Perez, Mamadou Daffé, Christophe Guilhot
Université de Toulouse, UPS, IPBS, Toulouse, France
Caroline Demangel, Nadine Honoré
Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, Paris, France

Corresponding Author

Email: Christophe.Guilhot@ipbs.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GT CD MD CG. Performed the experiments: GT CAD CD WM PC AR NH NFB EP. Analyzed the data: GT CAD CD PC CG. Wrote the paper: GT CD MD CG.