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Research Article

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

  • Laura I. Levi equal contributor,

    equal contributor Contributed equally to this work with: Laura I. Levi, Nina F. Gnädig

    Affiliation: Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France

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  • Nina F. Gnädig equal contributor,

    equal contributor Contributed equally to this work with: Laura I. Levi, Nina F. Gnädig

    Affiliation: Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France

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  • Stéphanie Beaucourt,

    Affiliation: Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France

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  • Malia J. McPherson,

    Affiliation: Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France

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  • Bruno Baron,

    Affiliation: Institut Pasteur, Plate Forme de Biophysique des Macromolécules et de leurs Interactions, Paris, France

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  • Jamie J. Arnold,

    Affiliation: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Marco Vignuzzi mail

    marco.vignuzzi@pasteur.fr

    Affiliation: Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France

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  • Published: October 28, 2010
  • DOI: 10.1371/journal.ppat.1001163

About the Authors

Laura I. Levi, Nina F. Gnädig, Stéphanie Beaucourt, Malia J. McPherson, Marco Vignuzzi
Institut Pasteur, Viral Populations and Pathogenesis Lab and CNRS URA3015, Paris, France
Bruno Baron
Institut Pasteur, Plate Forme de Biophysique des Macromolécules et de leurs Interactions, Paris, France
Jamie J. Arnold
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

Corresponding Author

Email: marco.vignuzzi@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LIL NFG JJA MV. Performed the experiments: LIL NFG SB MJM JJA MV. Analyzed the data: LIL NFG SB MJM BB JJA MV. Contributed reagents/materials/analysis tools: BB JJA. Wrote the paper: JJA MV.