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Research Article

Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry

  • Matteo Porotto mail,

    Map2028@med.Cornell.edu (MP); anm2047@med.Cornell.edu (AM)

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Barry Rockx,

    Affiliation: Laboratory of Virology, Division of Intramural research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Christine C. Yokoyama,

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Aparna Talekar,

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Ilaria DeVito,

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Laura M. Palermo,

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Jie Liu,

    Affiliation: Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Riccardo Cortese,

    Affiliation: CEINGE, Naples, Italy

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  • Min Lu,

    Affiliation: Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Heinz Feldmann,

    Affiliation: Laboratory of Virology, Division of Intramural research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Antonello Pessi,

    Affiliation: PeptiPharma, Rome, Italy

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  • Anne Moscona mail

    Map2028@med.Cornell.edu (MP); anm2047@med.Cornell.edu (AM)

    Affiliation: Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Published: October 28, 2010
  • DOI: 10.1371/journal.ppat.1001168

About the Authors

Matteo Porotto, Christine C. Yokoyama, Aparna Talekar, Ilaria DeVito, Laura M. Palermo, Anne Moscona
Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
Barry Rockx, Heinz Feldmann
Laboratory of Virology, Division of Intramural research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Jie Liu, Min Lu
Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, United States of America
Riccardo Cortese
CEINGE, Naples, Italy
Antonello Pessi
PeptiPharma, Rome, Italy

Corresponding Authors

Competing Interests

Matteo Porotto and Anne Moscona comment on published articles for Faculty of 1000 (virology section).

Author Contributions

Conceived and designed the experiments: MP BR LMP JL RC ML HF AP AM. Performed the experiments: MP BR CCY AT ID LMP JL. Analyzed the data: MP BR CCY AT ID LMP JL RC ML HF AP AM. Contributed reagents/materials/analysis tools: MP LMP RC HF AM. Wrote the paper: MP CCY ML HF AP AM.