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Research Article

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

  • Aartjan J. W. te Velthuis,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Sjoerd H. E. van den Worm,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Amy C. Sims,

    Affiliation: Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Ralph S. Baric,

    Affiliation: Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Eric J. Snijder mail,

    e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Martijn J. van Hemert mail

    e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.ppat.1001176

About the Authors

Aartjan J. W. te Velthuis, Sjoerd H. E. van den Worm, Eric J. Snijder, Martijn J. van Hemert
Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Amy C. Sims, Ralph S. Baric
Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJWtV SHEvdW EJS MJvH. Performed the experiments: AJWtV SHEvdW MJvH. Analyzed the data: AJWtV SHEvdW ACS RSB EJS MJvH. Contributed reagents/materials/analysis tools: ACS RSB. Wrote the paper: AJWtV EJS MJvH.