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Research Article

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

  • Louise Slater,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom

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  • Nathan W. Bartlett,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom

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  • Jennifer J. Haas,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom

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  • Jie Zhu,

    Affiliation: Lung Pathology, National Heart & Lung Institute, Imperial College London, London, United Kingdom

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  • Simon D. Message,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, Imperial Healthcare NHS Trust, London, United Kingdom

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  • Ross P. Walton,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom

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  • Annemarie Sykes,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom, Imperial Healthcare NHS Trust, London, United Kingdom

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  • Samer Dahdaleh,

    Affiliation: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom

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  • Deborah L. Clarke,

    Affiliations: Centre for Respiratory Infection, London, United Kingdom, Respiratory Pharmacology, National Heart & Lung Institute, Imperial College London, London, United Kingdom

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  • Maria G. Belvisi,

    Affiliations: Centre for Respiratory Infection, London, United Kingdom, Respiratory Pharmacology, National Heart & Lung Institute, Imperial College London, London, United Kingdom

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  • Onn M. Kon,

    Affiliations: Centre for Respiratory Infection, London, United Kingdom, Imperial Healthcare NHS Trust, London, United Kingdom

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  • Takashi Fujita,

    Affiliation: Institute of Virus Research, Kyoto University, Kyoto, Japan

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  • Peter K. Jeffery,

    Affiliation: Lung Pathology, National Heart & Lung Institute, Imperial College London, London, United Kingdom

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  • Sebastian L. Johnston,

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom, Imperial Healthcare NHS Trust, London, United Kingdom

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  • Michael R. Edwards mail

    michael.edwards@imperial.ac.uk

    Affiliations: Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom, Centre for Respiratory Infection, London, United Kingdom

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.ppat.1001178

About the Authors

Louise Slater, Nathan W. Bartlett, Jennifer J. Haas, Simon D. Message, Ross P. Walton, Annemarie Sykes, Samer Dahdaleh, Sebastian L. Johnston, Michael R. Edwards
Department of Respiratory Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom
Louise Slater, Nathan W. Bartlett, Jennifer J. Haas, Ross P. Walton, Annemarie Sykes, Sebastian L. Johnston, Michael R. Edwards
MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
Louise Slater, Nathan W. Bartlett, Jennifer J. Haas, Ross P. Walton, Annemarie Sykes, Deborah L. Clarke, Maria G. Belvisi, Onn M. Kon, Sebastian L. Johnston, Michael R. Edwards
Centre for Respiratory Infection, London, United Kingdom
Jie Zhu, Peter K. Jeffery
Lung Pathology, National Heart & Lung Institute, Imperial College London, London, United Kingdom
Simon D. Message, Annemarie Sykes, Onn M. Kon, Sebastian L. Johnston
Imperial Healthcare NHS Trust, London, United Kingdom
Deborah L. Clarke, Maria G. Belvisi
Respiratory Pharmacology, National Heart & Lung Institute, Imperial College London, London, United Kingdom
Takashi Fujita
Institute of Virus Research, Kyoto University, Kyoto, Japan

Corresponding Author

Email: michael.edwards@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LS NWB JZ SDM RPW AS MGB TF PKJ SLJ MRE. Performed the experiments: LS NWB JJH JZ SDM RPW AS SD DLC MRE. Analyzed the data: LS NWB JJH RPW SD MRE. Contributed reagents/materials/analysis tools: DLC MGB OMK TF PKJ. Wrote the paper: LS SLJ MRE.