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Research Article

CO2 Acts as a Signalling Molecule in Populations of the Fungal Pathogen Candida albicans

  • Rebecca A. Hall,

    Affiliations: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Luisa De Sordi,

    Affiliation: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom

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  • Donna M. MacCallum,

    Affiliation: School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Hüsnü Topal,

    Affiliation: Department of Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany

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  • Rebecca Eaton,

    Affiliation: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom

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  • James W. Bloor,

    Affiliation: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom

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  • Gary K. Robinson,

    Affiliation: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom

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  • Lonny R. Levin,

    Affiliation: Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Jochen Buck,

    Affiliation: Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Yue Wang,

    Affiliation: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, Singapore

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  • Neil A. R. Gow,

    Affiliation: School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Clemens Steegborn,

    Affiliations: Department of Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany, Department of Biochemistry, University of Bayreuth, Bayreuth, Germany

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  • Fritz A. Mühlschlegel mail

    F.A.Muhlschlegel@kent.ac.uk

    Affiliations: School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom, East Kent Hospitals University NHS Foundation Trust, Clinical Microbiology Service, William Harvey Hospital, Ashford, Kent, United Kingdom

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  • Published: November 18, 2010
  • DOI: 10.1371/journal.ppat.1001193

About the Authors

Rebecca A. Hall, Luisa De Sordi, Rebecca Eaton, James W. Bloor, Gary K. Robinson, Fritz A. Mühlschlegel
School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
Rebecca A. Hall, Donna M. MacCallum, Neil A. R. Gow
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
Hüsnü Topal, Clemens Steegborn
Department of Physiological Chemistry, Ruhr-University Bochum, Bochum, Germany
Lonny R. Levin, Jochen Buck
Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, United States of America
Yue Wang
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, Singapore
Clemens Steegborn
Department of Biochemistry, University of Bayreuth, Bayreuth, Germany
Fritz A. Mühlschlegel
East Kent Hospitals University NHS Foundation Trust, Clinical Microbiology Service, William Harvey Hospital, Ashford, Kent, United Kingdom

Corresponding Author

Email: F.A.Muhlschlegel@kent.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RAH DMM GKR YW CS FAM. Performed the experiments: RAH LDS DMM HT RE YW. Analyzed the data: RAH LDS JWB GKR LRL JB YW NARG CS FAM. Contributed reagents/materials/analysis tools: JWB YW NARG. Wrote the paper: RAH LDS DMM GKR LRL JB CS FAM.