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Research Article

Modelling the Evolution and Spread of HIV Immune Escape Mutants

  • Helen R. Fryer,

    Affiliation: The Institute for Emerging Infections, The James Martin 21st Century School, Department of Zoology, Oxford University, Oxford, United Kingdom

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  • John Frater,

    Affiliation: The Institute for Emerging Infections, The James Martin 21st Century School, The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Anna Duda,

    Affiliation: The Institute for Emerging Infections, The James Martin 21st Century School, The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Mick G. Roberts,

    Affiliation: Institute of Information and Mathematical Sciences and New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand

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  • The SPARTAC Trial Investigators,
  • Rodney E. Phillips,

    Affiliation: The Institute for Emerging Infections, The James Martin 21st Century School, The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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  • Angela R. McLean mail

    angela.mclean@zoo.ox.ac.uk

    Affiliation: The Institute for Emerging Infections, The James Martin 21st Century School, Department of Zoology, Oxford University, Oxford, United Kingdom

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  • Published: November 18, 2010
  • DOI: 10.1371/journal.ppat.1001196

About the Authors

Helen R. Fryer, Angela R. McLean
The Institute for Emerging Infections, The James Martin 21st Century School, Department of Zoology, Oxford University, Oxford, United Kingdom
John Frater, Anna Duda, Rodney E. Phillips
The Institute for Emerging Infections, The James Martin 21st Century School, The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom
Mick G. Roberts
Institute of Information and Mathematical Sciences and New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand

Corresponding Author

Email: angela.mclean@zoo.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JF REP ARM. Performed the experiments: JF AD. Analyzed the data: HRF JF AD MGR ARM. Wrote the paper: HRF ARM.