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Research Article

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

  • John J. Miles equal contributor mail,

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    milesjj@cardiff.ac.uk

    Affiliations: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom, Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

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  • Anna M. Bulek equal contributor,

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • David K. Cole equal contributor,

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Emma Gostick,

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Andrea J. A. Schauenburg,

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Garry Dolton,

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Vanessa Venturi,

    Affiliation: Computational Biology Unit, Centre for Vascular Research, University of New South Wales, Kensington, Australia

    X
  • Miles P. Davenport,

    Affiliation: Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia

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  • Mai Ping Tan,

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Scott R. Burrows,

    Affiliation: Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

    X
  • Linda Wooldridge,

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • David A. Price equal contributor,

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Pierre J. Rizkallah equal contributor,

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Andrew K. Sewell equal contributor

    equal contributor Contributed equally to this work with: John J. Miles, Anna M. Bulek, David K. Cole, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell

    Affiliation: Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom

    X
  • Published: November 18, 2010
  • DOI: 10.1371/journal.ppat.1001198

About the Authors

John J. Miles, Anna M. Bulek, David K. Cole, Emma Gostick, Andrea J. A. Schauenburg, Garry Dolton, Mai Ping Tan, Linda Wooldridge, David A. Price, Pierre J. Rizkallah, Andrew K. Sewell
Department of Infection, Immunity and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
John J. Miles, Scott R. Burrows
Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Vanessa Venturi
Computational Biology Unit, Centre for Vascular Research, University of New South Wales, Kensington, Australia
Miles P. Davenport
Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia

Corresponding Author

Email: milesjj@cardiff.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JJM DAP PJR AKS. Performed the experiments: JJM AMB DKC EG AJAS GD VV MPT. Analyzed the data: JJM AMB DKC VV MPD SRB LW DAP PJR AKS. Contributed reagents/materials/analysis tools: JJM DKC. Wrote the paper: JJM SRB DAP PJR AKS.