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Research Article

SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons

  • Felix L. Yeh,

    Affiliation: Department of Physiology, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Min Dong,

    Affiliation: New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Jun Yao,

    Affiliation: Department of Physiology, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America

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  • William H. Tepp,

    Affiliation: Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Guangyun Lin,

    Affiliation: Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Eric A. Johnson,

    Affiliation: Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Edwin R. Chapman mail

    chapman@physiology.wisc.edu

    Affiliation: Department of Physiology, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Published: November 24, 2010
  • DOI: 10.1371/journal.ppat.1001207

About the Authors

Felix L. Yeh, Jun Yao, Edwin R. Chapman
Department of Physiology, Howard Hughes Medical Institute, University of Wisconsin, Madison, Wisconsin, United States of America
Min Dong
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America
William H. Tepp, Guangyun Lin, Eric A. Johnson
Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

Corresponding Author

Email: chapman@physiology.wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FLY MD JY ERC. Performed the experiments: FLY MD JY. Analyzed the data: FLY MD JY. Contributed reagents/materials/analysis tools: WHT GL EAJ. Wrote the paper: FLY ERC.