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Research Article

Patients with Discordant Responses to Antiretroviral Therapy Have Impaired Killing of HIV-Infected T Cells

  • Sekar Natesampillai,

    Affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Zilin Nie,

    Affiliation: University of Michigan, Ann Arbor, Michigan, United States of America

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  • Nathan W. Cummins,

    Affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Dirk Jochmans,

    Affiliation: Tibotec BVBA, Mechelen, Belgium

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  • Gary D. Bren,

    Affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Jonathan B. Angel,

    Affiliation: Immunodeficiency Clinic, Ottawa Hospital, Ottawa, Ontario, Canada

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  • Andrew D. Badley mail

    badley.andrew@mayo.edu

    Affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Published: November 24, 2010
  • DOI: 10.1371/journal.ppat.1001213

About the Authors

Sekar Natesampillai, Nathan W. Cummins, Gary D. Bren, Andrew D. Badley
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
Zilin Nie
University of Michigan, Ann Arbor, Michigan, United States of America
Dirk Jochmans
Tibotec BVBA, Mechelen, Belgium
Jonathan B. Angel
Immunodeficiency Clinic, Ottawa Hospital, Ottawa, Ontario, Canada

Corresponding Author

Email: badley.andrew@mayo.edu

Competing Interests

ADB is named on a patent application for Casp8p41.

Author Contributions

Conceived and designed the experiments: SN ZN NWC GDB ADB. Performed the experiments: SN ZN NWC GDB. Analyzed the data: SN ZN NWC GDB ADB. Contributed reagents/materials/analysis tools: DJ JBA. Wrote the paper: ADB.