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Research Article

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection

  • Dimitra Peppa,

    Affiliations: Division of Infection and Immunity, UCL, London, United Kingdom, Centre for Sexual Health and HIV Research, UCL, London, United Kingdom

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  • Lorenzo Micco,

    Affiliation: Division of Infection and Immunity, UCL, London, United Kingdom

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  • Alia Javaid,

    Affiliation: Centre for Digestive Disease, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Patrick T. F. Kennedy,

    Affiliation: Centre for Digestive Disease, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Anna Schurich,

    Affiliation: Division of Infection and Immunity, UCL, London, United Kingdom

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  • Claire Dunn,

    Affiliation: Division of Infection and Immunity, UCL, London, United Kingdom

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  • Celeste Pallant,

    Affiliation: Division of Infection and Immunity, UCL, London, United Kingdom

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  • Gidon Ellis,

    Affiliation: Division of Infection and Immunity, UCL, London, United Kingdom

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  • Pooja Khanna,

    Affiliations: Division of Infection and Immunity, UCL, London, United Kingdom, Centre for Hepatology, Hampstead Campus, Royal Free & University College Medical School, London, United Kingdom

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  • Geoffrey Dusheiko,

    Affiliation: Centre for Hepatology, Hampstead Campus, Royal Free & University College Medical School, London, United Kingdom

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  • Richard J. Gilson,

    Affiliation: Centre for Sexual Health and HIV Research, UCL, London, United Kingdom

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  • Mala K. Maini mail

    m.maini@ucl.ac.uk

    Affiliations: Division of Infection and Immunity, UCL, London, United Kingdom, Centre for Sexual Health and HIV Research, UCL, London, United Kingdom, Centre for Digestive Disease, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Published: December 16, 2010
  • DOI: 10.1371/journal.ppat.1001227

About the Authors

Dimitra Peppa, Lorenzo Micco, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Mala K. Maini
Division of Infection and Immunity, UCL, London, United Kingdom
Dimitra Peppa, Richard J. Gilson, Mala K. Maini
Centre for Sexual Health and HIV Research, UCL, London, United Kingdom
Alia Javaid, Patrick T. F. Kennedy, Mala K. Maini
Centre for Digestive Disease, Barts and The London School of Medicine and Dentistry, London, United Kingdom
Pooja Khanna, Geoffrey Dusheiko
Centre for Hepatology, Hampstead Campus, Royal Free & University College Medical School, London, United Kingdom

Corresponding Author

Email: m.maini@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DP CD CP MKM. Performed the experiments: DP LM AJ GE. Analyzed the data: DP LM AS MKM. Contributed reagents/materials/analysis tools: AJ PTFK PK GD RJG. Wrote the paper: DP MKM.