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Research Article

Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure

  • Tommi A. White,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Alberto Bartesaghi,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Mario J. Borgnia,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Joel R. Meyerson,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • M. Jason V. de la Cruz,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Julian W. Bess,

    Affiliation: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Rachna Nandwani,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • James A. Hoxie,

    Affiliation: Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Jeffrey D. Lifson,

    Affiliation: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Jacqueline L. S. Milne,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Sriram Subramaniam mail

    ss1@nih.gov

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Published: December 23, 2010
  • DOI: 10.1371/journal.ppat.1001249

About the Authors

Tommi A. White, Alberto Bartesaghi, Mario J. Borgnia, Joel R. Meyerson, M. Jason V. de la Cruz, Rachna Nandwani, Jacqueline L. S. Milne, Sriram Subramaniam
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
Julian W. Bess, Jeffrey D. Lifson
AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America
James A. Hoxie
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: ss1@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TAW SS. Performed the experiments: TAW AB MJB JRM SS. Analyzed the data: TAW AB MJB JRM MJVdLC RN JAH JDL SS. Contributed reagents/materials/analysis tools: AB MJB JWB JAH JDL SS. Wrote the paper: TAW JLSM SS. All co-authors reviewed and provided input on the text of the manuscript.