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Research Article

Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

  • Guido Ferrari equal contributor mail,

    equal contributor Contributed equally to this work with: Guido Ferrari, Bette Korber

    gflmp@duke.edu

    Affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Bette Korber equal contributor,

    equal contributor Contributed equally to this work with: Guido Ferrari, Bette Korber

    Affiliation: Los Alamos National Laboratory, Theoretical Division, Los Alamos, New Mexico, United States of America

    X
  • Nilu Goonetilleke,

    Affiliation: University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom

    X
  • Michael K. P. Liu,

    Affiliation: University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom

    X
  • Emma L. Turnbull,

    Affiliation: Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Newbury, United Kingdom

    X
  • Jesus F. Salazar-Gonzalez,

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Natalie Hawkins,

    Affiliation: VID Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Steve Self,

    Affiliation: VID Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Sydeaka Watson,

    Affiliations: Los Alamos National Laboratory, Theoretical Division, Los Alamos, New Mexico, United States of America, Departmental of Statistical Sciences, Baylor University, Waco, Texas, United States of America

    X
  • Michael R. Betts,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Cynthia Gay,

    Affiliation: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Kara McGhee,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Pierre Pellegrino,

    Affiliation: Centre for Sexual Health & HIV Research, Mortimer Market Centre, London, United Kingdom

    X
  • Ian Williams,

    Affiliation: Centre for Sexual Health & HIV Research, Mortimer Market Centre, London, United Kingdom

    X
  • Georgia D. Tomaras,

    Affiliations: Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Barton F. Haynes,

    Affiliations: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Clive M. Gray,

    Affiliation: AIDS Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa

    X
  • Persephone Borrow,

    Affiliation: Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Newbury, United Kingdom

    X
  • Mario Roederer,

    Affiliation: Vaccine Research Center, National Institute of Health, Bethesda, Maryland, United States of America

    X
  • Andrew J. McMichael,

    Affiliation: University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom

    X
  • Kent J. Weinhold

    Affiliations: Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Published: February 10, 2011
  • DOI: 10.1371/journal.ppat.1001273

About the Authors

Guido Ferrari, Georgia D. Tomaras, Kent J. Weinhold
Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
Bette Korber, Sydeaka Watson
Los Alamos National Laboratory, Theoretical Division, Los Alamos, New Mexico, United States of America
Nilu Goonetilleke, Michael K. P. Liu, Andrew J. McMichael
University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
Emma L. Turnbull, Persephone Borrow
Nuffield Department of Clinical Medicine, University of Oxford, The Jenner Institute, Newbury, United Kingdom
Jesus F. Salazar-Gonzalez
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Natalie Hawkins, Steve Self
VID Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Sydeaka Watson
Departmental of Statistical Sciences, Baylor University, Waco, Texas, United States of America
Michael R. Betts
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Cynthia Gay
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Kara McGhee, Barton F. Haynes
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Pierre Pellegrino, Ian Williams
Centre for Sexual Health & HIV Research, Mortimer Market Centre, London, United Kingdom
Georgia D. Tomaras, Barton F. Haynes, Kent J. Weinhold
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
Clive M. Gray
AIDS Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
Mario Roederer
Vaccine Research Center, National Institute of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: gflmp@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GF BK NG MKPL ELT GDT BFH CMG PB MR AJM KJW. Performed the experiments: GF BK NG MKPL ELT JFSG. Analyzed the data: GF BK JFSG NH SS SW MRB MR. Contributed reagents/materials/analysis tools: MRB CG KM PP IW MR. Wrote the paper: GF BK NG MKPL ELT CG KM PP IW GDT BFH CMG PB MR AJM KJW. Patient recruitment and management provision of clinical data: CG KM PP IW.