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Research Article

Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis

  • Patrick D. Olson,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Lisa J. Kuechenmeister,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Kelsi L. Anderson,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Sonja Daily,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Karen E. Beenken,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

    X
  • Christelle M. Roux,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Michelle L. Reniere,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Tami L. Lewis,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • William J. Weiss,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • Mark Pulse,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • Phung Nguyen,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

    X
  • Jerry W. Simecka,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • John M. Morrison,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Khalid Sayood,

    Affiliation: Department of Electrical Engineering, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Oluwatoyin A. Asojo,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Mark S. Smeltzer,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Eric P. Skaar,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Paul M. Dunman mail

    Paul_Dunman@urmc.rochester.edu

    Affiliations: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America

    X
  • Published: February 10, 2011
  • DOI: 10.1371/journal.ppat.1001287

About the Authors

Patrick D. Olson, Lisa J. Kuechenmeister, Kelsi L. Anderson, Christelle M. Roux, Tami L. Lewis, John M. Morrison, Oluwatoyin A. Asojo, Paul M. Dunman
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Sonja Daily, Karen E. Beenken, Mark S. Smeltzer
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Michelle L. Reniere, Eric P. Skaar
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
William J. Weiss, Mark Pulse, Phung Nguyen, Jerry W. Simecka
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America
Khalid Sayood
Department of Electrical Engineering, University of Nebraska, Lincoln, Nebraska, United States of America
Paul M. Dunman
Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America

Corresponding Author

Email: Paul_Dunman@urmc.rochester.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWS MSS EPS PMD. Performed the experiments: PDO LJK KLA SD KEB CMR MLR TLL WJW MP PN JMM OAA. Analyzed the data: PDO LJK KLA KEB WJW JMM KS MSS EPS PMD. Contributed reagents/materials/analysis tools: OAA. Wrote the paper: PDO MSS EPS PMD.