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Research Article

Targeted Disruption of py235ebp-1: Invasion of Erythrocytes by Plasmodium yoelii Using an Alternative Py235 Erythrocyte Binding Protein

  • Solabomi A. Ogun mail,

    sogun@nimr.mrc.ac.uk (SAO); aholder@nimr.mrc.ac.uk (AAH)

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom

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  • Rita Tewari,

    Affiliation: Institute of Genetics, University of Nottingham, Nottingham, United Kingdom

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  • Thomas D. Otto,

    Affiliation: Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Steven A. Howell,

    Affiliation: Protein Structure, MRC National Institute for Medical Research, London, United Kingdom

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  • Ellen Knuepfer,

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom

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  • Deirdre A. Cunningham,

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom

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  • Zhengyao Xu,

    Affiliation: Protein Structure, MRC National Institute for Medical Research, London, United Kingdom

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  • Arnab Pain,

    Affiliations: Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Computational Bioscience Research Center, Chemical and Life Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

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  • Anthony A. Holder mail

    sogun@nimr.mrc.ac.uk (SAO); aholder@nimr.mrc.ac.uk (AAH)

    Affiliation: Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom

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  • Published: February 17, 2011
  • DOI: 10.1371/journal.ppat.1001288

About the Authors

Solabomi A. Ogun, Ellen Knuepfer, Deirdre A. Cunningham, Anthony A. Holder
Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
Rita Tewari
Institute of Genetics, University of Nottingham, Nottingham, United Kingdom
Thomas D. Otto, Arnab Pain
Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Steven A. Howell, Zhengyao Xu
Protein Structure, MRC National Institute for Medical Research, London, United Kingdom
Arnab Pain
Computational Bioscience Research Center, Chemical and Life Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAO RT AAH. Performed the experiments: SAO TDO SAH ZX. Analyzed the data: SAO TDO SAH AP AAH. Contributed reagents/materials/analysis tools: RT EK DAC. Wrote the paper: SAO AAH.