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Research Article

A Viral microRNA Cluster Strongly Potentiates the Transforming Properties of a Human Herpesvirus

  • Regina Feederle,

    Affiliation: Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany

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  • Sarah D. Linnstaedt,

    Affiliation: Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Helmut Bannert,

    Affiliation: Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany

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  • Helge Lips,

    Affiliation: Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany

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  • Maja Bencun,

    Affiliation: Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany

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  • Bryan R. Cullen,

    Affiliation: Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Henri-Jacques Delecluse mail

    h.delecluse@dkfz-heidelberg.de

    Affiliation: Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany

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  • Published: February 17, 2011
  • DOI: 10.1371/journal.ppat.1001294

About the Authors

Regina Feederle, Helmut Bannert, Helge Lips, Maja Bencun, Henri-Jacques Delecluse
Department of Virus Associated Tumours, German Cancer Research Center, Heidelberg, Germany
Sarah D. Linnstaedt, Bryan R. Cullen
Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: h.delecluse@dkfz-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BRC HJD. Performed the experiments: RF SDL HB HL MB HJD. Analyzed the data: RF SDL MB BRC HJD. Contributed reagents/materials/analysis tools: SDL BRC. Wrote the paper: RF BRC HJD.