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Research Article

DNA Damage and Reactive Nitrogen Species are Barriers to Vibrio cholerae Colonization of the Infant Mouse Intestine

  • Bryan W. Davies,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ryan W. Bogard,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Nicole M. Dupes,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Tyler A. I. Gerstenfeld,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lyle A. Simmons,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • John J. Mekalanos mail

    jmekalanos@hms.harvard.edu.

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: February 17, 2011
  • DOI: 10.1371/journal.ppat.1001295

About the Authors

Bryan W. Davies, Ryan W. Bogard, Tyler A. I. Gerstenfeld, John J. Mekalanos
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Nicole M. Dupes, Lyle A. Simmons
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: jmekalanos@hms.harvard.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BWD RWB LAS JJM. Performed the experiments: BWD RWB NMD TAIG. Analyzed the data: BWD RWB NMD TAIG LAS JJM. Contributed reagents/materials/analysis tools: BWD RWB LAS JJM. Wrote the paper: BWD RWB TAIG LAS JJM.