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Research Article

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission

  • Fatima Nawaz equal contributor,

    equal contributor Contributed equally to this work with: Fatima Nawaz, Claudia Cicala

    Affiliations: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New York University School of Medicine Sackler Institute of Graduate Biomedical Sciences, New York, New York, United States of America

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  • Claudia Cicala equal contributor,

    equal contributor Contributed equally to this work with: Fatima Nawaz, Claudia Cicala

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Donald Van Ryk,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Katharine E. Block,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Katija Jelicic,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jonathan P. McNally,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Olajumoke Ogundare,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Massimiliano Pascuccio,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nikita Patel,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Danlan Wei,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Anthony S. Fauci,

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • James Arthos mail

    jarthos@niaid.nih.gov

    Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.ppat.1001301

About the Authors

Fatima Nawaz, Claudia Cicala, Donald Van Ryk, Katharine E. Block, Katija Jelicic, Jonathan P. McNally, Olajumoke Ogundare, Massimiliano Pascuccio, Nikita Patel, Danlan Wei, Anthony S. Fauci, James Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Fatima Nawaz
New York University School of Medicine Sackler Institute of Graduate Biomedical Sciences, New York, New York, United States of America

Corresponding Author

Email: jarthos@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FN CC DVR KEB KJ JPM OO MP NP DW ASF JA. Performed the experiments: FN CC DVR KEB KJ JPM OO MP NP DW. Analyzed the data: FN CC DVR KEB KJ JPM OO MP NP DW ASF JA. Contributed reagents/materials/analysis tools: DVR OO MP NP DW. Wrote the paper: FN CC DVR KEB KJ JPM OO MP NP DW ASF JA.