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Research Article

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

  • Sang-Uk Seo,

    Affiliation: Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea

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  • Hyung-Joon Kwon,

    Affiliation: Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea

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  • Hyun-Jeong Ko,

    Affiliations: Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea, Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, South Korea

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  • Young-Ho Byun,

    Affiliation: Department of Biotechnology, College of Engineering, Yonsei University, Seoul, South Korea

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  • Baik Lin Seong,

    Affiliation: Department of Biotechnology, College of Engineering, Yonsei University, Seoul, South Korea

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  • Satoshi Uematsu,

    Affiliation: Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

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  • Shizuo Akira,

    Affiliation: Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

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  • Mi-Na Kweon mail

    mnkweon@ivi.int

    Affiliation: Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.ppat.1001304

About the Authors

Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Mi-Na Kweon
Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea
Hyun-Jeong Ko
Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, South Korea
Young-Ho Byun, Baik Lin Seong
Department of Biotechnology, College of Engineering, Yonsei University, Seoul, South Korea
Satoshi Uematsu, Shizuo Akira
Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, and Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Corresponding Author

Email: mnkweon@ivi.int

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: S-U. Seo, M-N. Kweon. Performed the experiments: S-U. Seo, H-J Kwon, H-J. Ko, Y-H. Byun. Analyzed the data: S-U. Seo, H-J. Ko, B-L. Seong, S. Uematsu, S. Akira, M-N. Kweon. Contributed reagents/materials/analysis tools: B-L. Seong, S. Uematsu, S. Akira. Wrote the paper: S-U. Seo, M-N. Kweon.