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Research Article

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

  • Amitava Mukherjee,

    Affiliation: Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Stefanie A. Morosky,

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Elizabeth Delorme-Axford,

    Affiliation: Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Naomi Dybdahl-Sissoko,

    Affiliation: Picornavirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • M. Steven Oberste,

    Affiliation: Picornavirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Tianyi Wang,

    Affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Carolyn B. Coyne mail

    coynec2@pitt.edu

    Affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: March 10, 2011
  • DOI: 10.1371/journal.ppat.1001311

About the Authors

Amitava Mukherjee, Elizabeth Delorme-Axford
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Stefanie A. Morosky, Carolyn B. Coyne
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Naomi Dybdahl-Sissoko, M. Steven Oberste
Picornavirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Tianyi Wang
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Author

Email: coynec2@pitt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM CBC. Performed the experiments: AM SAM EDA NDS CBC. Analyzed the data: AM CBC. Contributed reagents/materials/analysis tools: NDS MSO TW. Wrote the paper: CBC.