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Research Article

Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice

  • Danielle Padilla equal contributor,

    equal contributor Contributed equally to this work with: Danielle Padilla, Vincent Béringue

    Affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

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  • Vincent Béringue equal contributor,

    equal contributor Contributed equally to this work with: Danielle Padilla, Vincent Béringue

    Affiliation: INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France

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  • Juan Carlos Espinosa,

    Affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

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  • Olivier Andreoletti,

    Affiliation: UMR INRA-ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France

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  • Emilie Jaumain,

    Affiliation: INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France

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  • Fabienne Reine,

    Affiliation: INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France

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  • Laetitia Herzog,

    Affiliation: INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France

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  • Alfonso Gutierrez-Adan,

    Affiliation: Departamento de Reproducción Animal-INIA, Madrid, Spain

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  • Belen Pintado,

    Affiliation: Departamento de Reproducción Animal-INIA, Madrid, Spain

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  • Hubert Laude,

    Affiliation: INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France

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  • Juan Maria Torres mail

    jmtorres@inia.es

    Affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

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  • Published: March 17, 2011
  • DOI: 10.1371/journal.ppat.1001319

About the Authors

Danielle Padilla, Juan Carlos Espinosa, Juan Maria Torres
Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Vincent Béringue, Emilie Jaumain, Fabienne Reine, Laetitia Herzog, Hubert Laude
INRA, UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, France
Olivier Andreoletti
UMR INRA-ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Alfonso Gutierrez-Adan, Belen Pintado
Departamento de Reproducción Animal-INIA, Madrid, Spain

Corresponding Author

Email: jmtorres@inia.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VB HL JMT. Performed the experiments: DP VB JCE OA EJ FR LH AGA BP. Analyzed the data: DP VB JCE OA HL JMT. Contributed reagents/materials/analysis tools: HL JMT. Wrote the paper: DP VB OA HL JMT.