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Research Article

Multiple Helminth Infection of the Skin Causes Lymphocyte Hypo-Responsiveness Mediated by Th2 Conditioning of Dermal Myeloid Cells

  • Peter C. Cook,

    Affiliation: Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom

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  • Sarah A. Aynsley,

    Affiliation: Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom

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  • Joseph D. Turner,

    Affiliation: Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom

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  • Gavin R. Jenkins,

    Affiliation: Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom

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  • Nico Van Rooijen,

    Affiliation: Department of Molecular Cell Biology, Vrjie Universiteit, Amsterdam, The Netherlands

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  • Mosiuoa Leeto,

    Affiliation: Division of Infectious Immunology, University of Cape Town, Cape Town, South Africa

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  • Frank Brombacher,

    Affiliation: Division of Infectious Immunology, University of Cape Town, Cape Town, South Africa

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  • Adrian P. Mountford mail

    adrian.mountford@york.ac.uk

    Affiliation: Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom

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  • Published: March 17, 2011
  • DOI: 10.1371/journal.ppat.1001323

About the Authors

Peter C. Cook, Sarah A. Aynsley, Joseph D. Turner, Gavin R. Jenkins, Adrian P. Mountford
Centre for Immunology and Infection, Department of Biology, The University of York, York, United Kingdom
Nico Van Rooijen
Department of Molecular Cell Biology, Vrjie Universiteit, Amsterdam, The Netherlands
Mosiuoa Leeto, Frank Brombacher
Division of Infectious Immunology, University of Cape Town, Cape Town, South Africa

Corresponding Author

Email: adrian.mountford@york.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PCC APM. Performed the experiments: PCC SAA JDT GRJ ML. Analyzed the data: PCC SAA JDT. Contributed reagents/materials/analysis tools: NVR ML FB. Wrote the paper: PCC JDT FB APM.