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Research Article

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

  • Erik de Vries,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Donna M. Tscherne,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, United States of America

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  • Marleen J. Wienholts,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Viviana Cobos-Jiménez,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Florine Scholte,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Adolfo García-Sastre,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, United States of America

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  • Peter J. M. Rottier,

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Cornelis A. M. de Haan mail

    c.a.m.dehaan@uu.nl

    Affiliation: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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  • Published: March 31, 2011
  • DOI: 10.1371/journal.ppat.1001329

About the Authors

Erik de Vries, Marleen J. Wienholts, Viviana Cobos-Jiménez, Florine Scholte, Peter J. M. Rottier, Cornelis A. M. de Haan
Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Donna M. Tscherne, Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, United States of America
Adolfo García-Sastre
Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, United States of America
Adolfo García-Sastre
Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, United States of America

Corresponding Author

Email: c.a.m.dehaan@uu.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EdV DMT AGS PJMR CAMdH. Performed the experiments: EdV DMT MJW VCJ FS. Analyzed the data: EdV DMT MJW VCJ FS. Wrote the paper: EdV DMT AGS PJMR CAMdH.