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Research Article

SLO-1-Channels of Parasitic Nematodes Reconstitute Locomotor Behaviour and Emodepside Sensitivity in Caenorhabditis elegans slo-1 Loss of Function Mutants

  • Claudia Welz equal contributor,

    equal contributor Contributed equally to this work with: Claudia Welz, Nina Krüger

    Affiliation: Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany

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  • Nina Krüger equal contributor,

    equal contributor Contributed equally to this work with: Claudia Welz, Nina Krüger

    Affiliation: Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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  • Monika Schniederjans,

    Affiliation: Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany

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  • Sandra M. Miltsch,

    Affiliation: Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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  • Jürgen Krücken,

    Affiliation: Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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  • Marcus Guest,

    Affiliation: School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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  • Lindy Holden-Dye,

    Affiliation: School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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  • Achim Harder,

    Affiliation: Bayer HealthCare AG, Animal Health, R&D-Parasiticides, Monheim, Germany

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  • Georg von Samson-Himmelstjerna mail

    gvsamson@vetmed.fu-berlin.de

    Affiliation: Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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  • Published: April 07, 2011
  • DOI: 10.1371/journal.ppat.1001330

About the Authors

Claudia Welz, Monika Schniederjans
Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany
Nina Krüger, Sandra M. Miltsch, Jürgen Krücken, Georg von Samson-Himmelstjerna
Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany
Marcus Guest, Lindy Holden-Dye
School of Biological Sciences, University of Southampton, Southampton, United Kingdom
Achim Harder
Bayer HealthCare AG, Animal Health, R&D-Parasiticides, Monheim, Germany

Corresponding Author

Email: gvsamson@vetmed.fu-berlin.de

Competing Interests

Achim Harder is employed by BayerHealthCare AG, which is developing veterinary pharmaceuticals including antiparasiticdal drugs like emodepside. This study was performed as a collaborative research project between Bayer HealthCare AG and the Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin as well as previously the Institute for Parasitology at the University of Veterinary Medicine, Hannover. Accordingly, both academic institutions received project specific reseach grants from Bayer HealthCare AG.

Author Contributions

Conceived and designed the experiments: CW NK LHD AH GvSH. Performed the experiments: CW NK MS SMM MG. Analyzed the data: CW NK MS SMM JK. Contributed reagents/materials/analysis tools: MG LHD AH GvSH. Wrote the paper: CW NK JK GvSH.