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Research Article

Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3

  • Robert J. W. Heath,

    Affiliations: Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Gastrointestinal Unit, Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • John M. Leong,

    Affiliation: Department of Molecular Genetics and Microbiology, UMass Medical School, Worcester, Massachusetts, United States of America

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  • Balázs Visegrády,

    Affiliation: Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, United Kingdom

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  • Laura M. Machesky,

    Affiliation: Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, United Kingdom

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  • Ramnik J. Xavier mail

    Xavier@molbiol.mgh.harvard.edu

    Affiliations: Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Gastrointestinal Unit, Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Published: April 07, 2011
  • DOI: 10.1371/journal.ppat.1001332

About the Authors

Robert J. W. Heath, Ramnik J. Xavier
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Robert J. W. Heath, Ramnik J. Xavier
Gastrointestinal Unit, Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
John M. Leong
Department of Molecular Genetics and Microbiology, UMass Medical School, Worcester, Massachusetts, United States of America
Balázs Visegrády, Laura M. Machesky
Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, United Kingdom
Ramnik J. Xavier
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: Xavier@molbiol.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RJWH JML RJX. Performed the experiments: RJWH. Analyzed the data: RJWH. Contributed reagents/materials/analysis tools: JML BV LMM. Wrote the paper: RJWH.