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Research Article

The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate

  • Srinika R. F. Ranasinghe mail,

    tao.dong@imm.ox.ac.uk (TD); srinika.ranasinghe@bnc.oxon-org (SRFR)

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

    Current address: The Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Holger B. Kramer,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Cynthia Wright,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Benedikt M. Kessler,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Katalin di Gleria,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Yonghong Zhang,

    Affiliations: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, BeiJing You'An Hospital, BeiJing Capital University, BeiJing, China

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  • Geraldine M. Gillespie,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Marie-Eve Blais,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Abigail Culshaw,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tica Pichulik,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Alison Simmons,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Sarah L. Rowland-Jones,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Andrew J. McMichael,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tao Dong mail

    tao.dong@imm.ox.ac.uk (TD); srinika.ranasinghe@bnc.oxon-org (SRFR)

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: May 12, 2011
  • DOI: 10.1371/journal.ppat.1001341

About the Authors

Srinika R. F. Ranasinghe, Katalin di Gleria, Yonghong Zhang, Geraldine M. Gillespie, Marie-Eve Blais, Abigail Culshaw, Tica Pichulik, Alison Simmons, Sarah L. Rowland-Jones, Andrew J. McMichael, Tao Dong
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Holger B. Kramer, Cynthia Wright, Benedikt M. Kessler
Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
Yonghong Zhang
BeiJing You'An Hospital, BeiJing Capital University, BeiJing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRFR TD. Performed the experiments: SRFR HBK CW KdG YZ MEB AC TP. Analyzed the data: SRFR BMK. Contributed reagents/materials/analysis tools: HBK CW BMK KdG GMG AS AJM TD. Wrote the paper: SRFR BMK SLRJ AJM TD.