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Research Article

Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines

  • Anne Frentzen,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Kathrin Hüging,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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  • Julia Bitzegeio,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Martina Friesland,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Sibylle Haid,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Juliane Gentzsch,

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Markus Hoffmann,

    Affiliation: Institute of Virology, University of Veterinary Medicine, Hannover, Germany

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  • Dirk Lindemann,

    Affiliation: Institute of Virology, Carl Gustav Carus Medical Facility, Technical University Dresden, Dresden, Germany

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  • Gert Zimmer,

    Affiliation: Institute of Virology and Immunoprophylaxis (IVI), Mittelhäusern, Switzerland

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  • Florian Zielecki,

    Affiliation: Institute of Virology, Philipps University Marburg, Marburg, Germany

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  • Friedemann Weber,

    Affiliation: Institute of Virology, Philipps University Marburg, Marburg, Germany

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  • Eike Steinmann equal contributor mail,

    equal contributor Contributed equally to this work with: Eike Steinmann, Thomas Pietschmann

    thomas.pietschmann@twincore.de (TP); eike.steinmann@twincore.de (ES)

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Thomas Pietschmann equal contributor mail

    equal contributor Contributed equally to this work with: Eike Steinmann, Thomas Pietschmann

    thomas.pietschmann@twincore.de (TP); eike.steinmann@twincore.de (ES)

    Affiliation: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

    X
  • Published: April 28, 2011
  • DOI: 10.1371/journal.ppat.1002029

About the Authors

Anne Frentzen, Kathrin Hüging, Julia Bitzegeio, Martina Friesland, Sibylle Haid, Juliane Gentzsch, Eike Steinmann, Thomas Pietschmann
Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
Markus Hoffmann
Institute of Virology, University of Veterinary Medicine, Hannover, Germany
Dirk Lindemann
Institute of Virology, Carl Gustav Carus Medical Facility, Technical University Dresden, Dresden, Germany
Gert Zimmer
Institute of Virology and Immunoprophylaxis (IVI), Mittelhäusern, Switzerland
Florian Zielecki, Friedemann Weber
Institute of Virology, Philipps University Marburg, Marburg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AF KH JB FW ES TP. Performed the experiments: AF KH MF SH FZ ES. Analyzed the data: AF KH JB JG FW ES TP. Contributed reagents/materials/analysis tools: MH DL GZ FW. Wrote the paper: AF ES TP. Editing of manuscript: KH JB MH DL GZ FW.