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Research Article

Transition of Plasmodium Sporozoites into Liver Stage-Like Forms Is Regulated by the RNA Binding Protein Pumilio

  • Carina S. S. Gomes-Santos equal contributor,

    equal contributor Contributed equally to this work with: Carina S. S. Gomes-Santos, Joanna Braks

    Affiliations: Malaria Unit, Instituto de Medicina Molecular, Lisboa, Portugal, PhD Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

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  • Joanna Braks equal contributor,

    equal contributor Contributed equally to this work with: Carina S. S. Gomes-Santos, Joanna Braks

    Affiliation: Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre, Leiden, The Netherlands

    X
  • Miguel Prudêncio,

    Affiliation: Malaria Unit, Instituto de Medicina Molecular, Lisboa, Portugal

    X
  • Céline Carret,

    Affiliation: Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisbon, Portugal

    X
  • Ana Rita Gomes,

    Affiliation: Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisbon, Portugal

    X
  • Arnab Pain,

    Affiliations: Pathogen Genetics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom, Computational Bioscience Research Center (CBRC), Chemical Life Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia

    X
  • Theresa Feltwell,

    Affiliation: Pathogen Genetics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

    X
  • Shahid Khan,

    Affiliation: Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre, Leiden, The Netherlands

    X
  • Andrew Waters mail,

    gmair@fm.ul.pt (GRM); andy.waters@glasgow.ac.uk (AW); mmota@fm.ul.pt (MM)

    Affiliations: Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre, Leiden, The Netherlands, Division of Infection and Immunity, Institute of Biomedical Life Sciences and Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland

    X
  • Chris Janse,

    Affiliation: Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre, Leiden, The Netherlands

    X
  • Gunnar R. Mair mail,

    gmair@fm.ul.pt (GRM); andy.waters@glasgow.ac.uk (AW); mmota@fm.ul.pt (MM)

    Affiliation: Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisbon, Portugal

    X
  • Maria M. Mota mail

    gmair@fm.ul.pt (GRM); andy.waters@glasgow.ac.uk (AW); mmota@fm.ul.pt (MM)

    Affiliation: Malaria Unit, Instituto de Medicina Molecular, Lisboa, Portugal

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  • Published: May 19, 2011
  • DOI: 10.1371/journal.ppat.1002046

About the Authors

Carina S. S. Gomes-Santos, Miguel Prudêncio, Maria M. Mota
Malaria Unit, Instituto de Medicina Molecular, Lisboa, Portugal
Carina S. S. Gomes-Santos
PhD Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
Joanna Braks, Shahid Khan, Andrew Waters, Chris Janse
Leiden Malaria Research Group, Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
Céline Carret, Ana Rita Gomes, Gunnar R. Mair
Molecular Parasitology Unit, Instituto de Medicina Molecular, Lisbon, Portugal
Arnab Pain, Theresa Feltwell
Pathogen Genetics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Arnab Pain
Computational Bioscience Research Center (CBRC), Chemical Life Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia
Andrew Waters
Division of Infection and Immunity, Institute of Biomedical Life Sciences and Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CSSGS JB MP CC SK AW CJ GRM MM. Performed the experiments: CSSGS JB MP CC ARG TF GRM. Analyzed the data: CSSGS JB MP CC ARG CJ GRM MM. Contributed reagents/materials/analysis tools: AP AW. Wrote the paper: CSSGS JB MP CC SK AW CJ GRM MM.