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Research Article

AAV Exploits Subcellular Stress Associated with Inflammation, Endoplasmic Reticulum Expansion, and Misfolded Proteins in Models of Cystic Fibrosis

  • Jarrod S. Johnson,

    Affiliations: Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Martina Gentzsch,

    Affiliations: Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Liqun Zhang,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Carla M. P. Ribeiro,

    Affiliations: Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Boris Kantor,

    Affiliation: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Tal Kafri,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Raymond J. Pickles,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • R. Jude Samulski mail

    rjs@med.unc.edu

    Affiliations: Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Published: May 19, 2011
  • DOI: 10.1371/journal.ppat.1002053

About the Authors

Jarrod S. Johnson, R. Jude Samulski
Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Jarrod S. Johnson, Liqun Zhang, Boris Kantor, Tal Kafri, Raymond J. Pickles, R. Jude Samulski
Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Martina Gentzsch, Liqun Zhang, Carla M. P. Ribeiro, Raymond J. Pickles, R. Jude Samulski
Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Martina Gentzsch
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Carla M. P. Ribeiro
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
Tal Kafri, Raymond J. Pickles
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: rjs@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JSJ RJP RJS. Performed the experiments: JSJ. Analyzed the data: JSJ MG LZ CMPR BK TK RJP RJS. Contributed reagents/materials/analysis tools: JSJ MG LZ CMPR BK TK RJP RJS. Wrote the paper: JSJ RJP RJS.