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Research Article

Reactive Oxygen Species Hydrogen Peroxide Mediates Kaposi's Sarcoma-Associated Herpesvirus Reactivation from Latency

  • Fengchun Ye,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Fuchun Zhou,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Roble G. Bedolla,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Tiffany Jones,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Xiufen Lei,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Tao Kang,

    Affiliation: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Moraima Guadalupe,

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Shou-Jiang Gao mail

    gaos@uthscsa.edu

    Affiliations: Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Published: May 19, 2011
  • DOI: 10.1371/journal.ppat.1002054

About the Authors

Fengchun Ye, Fuchun Zhou, Roble G. Bedolla, Tiffany Jones, Xiufen Lei, Tao Kang, Moraima Guadalupe, Shou-Jiang Gao
Tumor Virology Program, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
Fengchun Ye, Fuchun Zhou, Roble G. Bedolla, Xiufen Lei, Moraima Guadalupe, Shou-Jiang Gao
Department of Pediatrics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
Tiffany Jones
Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
Shou-Jiang Gao
Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Corresponding Author

Email: gaos@uthscsa.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJG FY. Performed the experiments: FY FZ RGB TJ XL TK SJG. Analyzed the data: FY SJG. Contributed reagents/materials/analysis tools: FY MG SJG. Wrote the paper: FY SJG.