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Research Article

Endemic Dengue Associated with the Co-Circulation of Multiple Viral Lineages and Localized Density-Dependent Transmission

  • Jayna Raghwani,

    Affiliation: University of Edinburgh, Institute of Evolutionary Biology, Ashworth Laboratories, Edinburgh, United Kingdom

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  • Andrew Rambaut,

    Affiliations: University of Edinburgh, Institute of Evolutionary Biology, Ashworth Laboratories, Edinburgh, United Kingdom, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Edward C. Holmes,

    Affiliations: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Vu Ty Hang,

    Affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Tran Tinh Hien,

    Affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Jeremy Farrar,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Bridget Wills,

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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  • Niall J. Lennon,

    Affiliation: Broad Institute of MIT & Harvard, Cambridge, Massachusetts, United States of America

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  • Bruce W. Birren,

    Affiliation: Broad Institute of MIT & Harvard, Cambridge, Massachusetts, United States of America

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  • Matthew R. Henn,

    Affiliation: Broad Institute of MIT & Harvard, Cambridge, Massachusetts, United States of America

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  • Cameron P. Simmons mail

    csimmons@oucru.org

    Affiliations: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

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  • Published: June 02, 2011
  • DOI: 10.1371/journal.ppat.1002064

About the Authors

Jayna Raghwani, Andrew Rambaut
University of Edinburgh, Institute of Evolutionary Biology, Ashworth Laboratories, Edinburgh, United Kingdom
Andrew Rambaut, Edward C. Holmes
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
Edward C. Holmes
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
Vu Ty Hang, Jeremy Farrar, Bridget Wills, Cameron P. Simmons
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Tran Tinh Hien, Cameron P. Simmons
Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Jeremy Farrar, Bridget Wills
Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Niall J. Lennon, Bruce W. Birren, Matthew R. Henn
Broad Institute of MIT & Harvard, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: csimmons@oucru.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CPS ECH AR. Performed the experiments: VTH TTH JF BW NJL BWB MRH CPS. Analyzed the data: JR. Wrote the paper: JR ECH CPS AR. Virus and geospatial data collection: VTH TTH JF BW BWB CPS.