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Research Article

Lymphoadenopathy during Lyme Borreliosis Is Caused by Spirochete Migration-Induced Specific B Cell Activation

  • Stefan S. Tunev,

    Affiliations: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America, Graduate Group in Comparative Pathology, University of California Davis, Davis, California, United States of America

    Current address: Medtronic Inc., Santa Rosa, California, United States of America

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  • Christine J. Hastey,

    Affiliations: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America, Graduate Group in Microbiology, University of California Davis, Davis, California, United States of America

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  • Emir Hodzic,

    Affiliation: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America

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  • Sunlian Feng,

    Affiliation: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America

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  • Stephen W. Barthold,

    Affiliations: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America, Graduate Group in Comparative Pathology, University of California Davis, Davis, California, United States of America, Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, California, United States of America, Graduate Group in Microbiology, University of California Davis, Davis, California, United States of America

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  • Nicole Baumgarth mail

    nbaumgarth@ucdavis.edu

    Affiliations: Center for Comparative Medicine, University of California Davis, Davis, California, United States of America, Graduate Group in Comparative Pathology, University of California Davis, Davis, California, United States of America, Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, California, United States of America, Graduate Group in Microbiology, University of California Davis, Davis, California, United States of America

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.ppat.1002066

About the Authors

Stefan S. Tunev, Christine J. Hastey, Emir Hodzic, Sunlian Feng, Stephen W. Barthold, Nicole Baumgarth
Center for Comparative Medicine, University of California Davis, Davis, California, United States of America
Stefan S. Tunev, Stephen W. Barthold, Nicole Baumgarth
Graduate Group in Comparative Pathology, University of California Davis, Davis, California, United States of America
Stephen W. Barthold, Nicole Baumgarth
Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, California, United States of America
Christine J. Hastey, Stephen W. Barthold, Nicole Baumgarth
Graduate Group in Microbiology, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: nbaumgarth@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SST CJH SWB NB. Performed the experiments: SST CJH EH. Analyzed the data: SST CJH EH SWB NB. Contributed reagents/materials/analysis tools: SF SWB NB. Wrote the paper: SST CJH SWB NB.