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Research Article

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

  • Zsuzsanna T. Varga,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Irene Ramos,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Rong Hai,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Mirco Schmolke,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Adolfo García-Sastre,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America, Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Ana Fernandez-Sesma,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America, Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Peter Palese mail

    peter.palese@mssm.edu

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Published: June 09, 2011
  • DOI: 10.1371/journal.ppat.1002067

About the Authors

Zsuzsanna T. Varga, Irene Ramos, Rong Hai, Mirco Schmolke, Adolfo García-Sastre, Ana Fernandez-Sesma, Peter Palese
Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America
Adolfo García-Sastre, Ana Fernandez-Sesma
Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine, New York City, New York, United States of America
Adolfo García-Sastre, Ana Fernandez-Sesma, Peter Palese
Department of Medicine, Mount Sinai School of Medicine, New York City, New York, United States of America

Corresponding Author

Email: peter.palese@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZTV IR MS AGS AFS PP. Performed the experiments: ZTV IR RH PP. Analyzed the data: ZTV IR MS AGS AFS PP. Contributed reagents/materials/analysis tools: ZTV IR RH MS AGS AFS PP. Wrote the paper: ZTV PP.