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Research Article

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

  • Yohei Watanabe mail,

    nabe@biken.osaka-u.ac.jp (YW); Ikuta@biken.osaka-u.ac.jp (KI)

    Affiliation: Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan

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  • Madiha S. Ibrahim,

    Affiliations: Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan, Department of Microbiology, Faculty of Veterinary Medicine, Alexandria University, Damanhour Branch, Egypt

    Current address: Department of Microbiology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt

    X
  • Hany F. Ellakany,

    Affiliation: Department of Poultry Diseases and Hygiene, Faculty of Veterinary Medicine, Alexandria University, Edfina Branch, Egypt

    X
  • Norihito Kawashita,

    Affiliations: Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

    X
  • Rika Mizuike,

    Affiliation: Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan

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  • Hiroaki Hiramatsu,

    Affiliation: Health Scientific Hills, College of Life and Health Sciences, Chubu University, Aichi, Japan

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  • Nogluk Sriwilaijaroen,

    Affiliations: Health Scientific Hills, College of Life and Health Sciences, Chubu University, Aichi, Japan, Faculty of Medicine, Thammasat University (Rangsit Campus), PathumThani, Thailand

    X
  • Tatsuya Takagi,

    Affiliations: Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

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  • Yasuo Suzuki,

    Affiliation: Health Scientific Hills, College of Life and Health Sciences, Chubu University, Aichi, Japan

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  • Kazuyoshi Ikuta mail

    nabe@biken.osaka-u.ac.jp (YW); Ikuta@biken.osaka-u.ac.jp (KI)

    Affiliation: Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan

    X
  • Published: May 26, 2011
  • DOI: 10.1371/journal.ppat.1002068

About the Authors

Yohei Watanabe, Madiha S. Ibrahim, Rika Mizuike, Kazuyoshi Ikuta
Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan
Madiha S. Ibrahim
Department of Microbiology, Faculty of Veterinary Medicine, Alexandria University, Damanhour Branch, Egypt
Hany F. Ellakany
Department of Poultry Diseases and Hygiene, Faculty of Veterinary Medicine, Alexandria University, Edfina Branch, Egypt
Norihito Kawashita, Tatsuya Takagi
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
Norihito Kawashita, Tatsuya Takagi
Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Hiroaki Hiramatsu, Nogluk Sriwilaijaroen, Yasuo Suzuki
Health Scientific Hills, College of Life and Health Sciences, Chubu University, Aichi, Japan
Nogluk Sriwilaijaroen
Faculty of Medicine, Thammasat University (Rangsit Campus), PathumThani, Thailand

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YW KI. Performed the experiments: YW MSI NK RM. Analyzed the data: YW MSI NK RM HH NS. Contributed reagents/materials/analysis tools: YW MSI HFE NK HH NS TT YS. Wrote the paper: YW YS KI.