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Research Article

MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

  • Qiong Wang,

    Affiliation: Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • David J. Miller,

    Affiliations: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Emily R. Bowman,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Deepti R. Nagarkar,

    Affiliation: Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Dina Schneider,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Ying Zhao,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Marisa J. Linn,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Adam M. Goldsmith,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • J. Kelley Bentley,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Umadevi S. Sajjan,

    Affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Marc B. Hershenson mail

    mhershen@umich.edu

    Affiliations: Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.ppat.1002070

About the Authors

Qiong Wang, Deepti R. Nagarkar, Marc B. Hershenson
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
David J. Miller
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
David J. Miller
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Emily R. Bowman, Dina Schneider, Ying Zhao, Marisa J. Linn, Adam M. Goldsmith, J. Kelley Bentley, Umadevi S. Sajjan, Marc B. Hershenson
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: mhershen@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QW DJM USS MBH. Performed the experiments: QW ERB DRN DS YZ MJL AMG JKB. Analyzed the data: QW DJM JKB USS MBH. Contributed reagents/materials/analysis tools: DJM. Wrote the paper: QW MBH.