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Research Article

Environmental Constraints Guide Migration of Malaria Parasites during Transmission

  • Janina Kristin Hellmann,

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

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  • Sylvia Münter,

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

    Current address: Carl Zeiss MicroImaging Labs, München, Germany

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  • Mikhail Kudryashev,

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

    Current address: Center for Cellular Imaging and Nano Analytics (C-CINA), Biozentrum, University of Basel, Basel, Switzerland

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  • Simon Schulz,

    Affiliation: Max Planck Institute for Metals Research, Department of New Materials and Biosystems, and University of Heidelberg, Department of Biophysical Chemistry, Stuttgart, Germany

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  • Kirsten Heiss,

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

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  • Ann-Kristin Müller,

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

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  • Kai Matuschewski,

    Affiliations: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany, Max Planck Institute for Infection Biology, Department of Parasitology, Berlin, Germany

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  • Joachim P. Spatz,

    Affiliation: Max Planck Institute for Metals Research, Department of New Materials and Biosystems, and University of Heidelberg, Department of Biophysical Chemistry, Stuttgart, Germany

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  • Ulrich S. Schwarz,

    Affiliation: Institute for Theoretical Physics and Bioquant, University of Heidelberg, Heidelberg, Germany

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  • Friedrich Frischknecht mail

    freddy.frischknecht@med.uni-heidelberg.de

    Affiliation: Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany

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  • Published: June 16, 2011
  • DOI: 10.1371/journal.ppat.1002080

About the Authors

Janina Kristin Hellmann, Sylvia Münter, Mikhail Kudryashev, Kirsten Heiss, Ann-Kristin Müller, Kai Matuschewski, Friedrich Frischknecht
Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany
Simon Schulz, Joachim P. Spatz
Max Planck Institute for Metals Research, Department of New Materials and Biosystems, and University of Heidelberg, Department of Biophysical Chemistry, Stuttgart, Germany
Kai Matuschewski
Max Planck Institute for Infection Biology, Department of Parasitology, Berlin, Germany
Ulrich S. Schwarz
Institute for Theoretical Physics and Bioquant, University of Heidelberg, Heidelberg, Germany

Corresponding Author

Email: freddy.frischknecht@med.uni-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKH SM FF. Performed the experiments: JKH SM. Analyzed the data: JKH SM MK. Contributed reagents/materials/analysis tools: MK SS JPS. Wrote the paper: JKH SM USS FF. Generated the GFP-tlp(-) parasite line: JKH KH AKM KM. Guided the study: JKH FF USS.