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Research Article

Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa

  • Pedro Eitz Ferrer,

    Affiliations: Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany, Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany, University of Freiburg, Faculty of Biology, Freiburg, Germany

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  • Stephanie Potthoff,

    Affiliation: Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany

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  • Susanne Kirschnek,

    Affiliation: Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany

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  • Georg Gasteiger,

    Affiliation: Institute of Virology and Clinical Cooperation Group “Antigen-specific Immunotherapy”, TechnischeUniversitätMünchen and Helmholtz ZentrumMünchen, Munich, Germany

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  • Wolfgang Kastenmüller,

    Affiliation: Institute of Virology and Clinical Cooperation Group “Antigen-specific Immunotherapy”, TechnischeUniversitätMünchen and Helmholtz ZentrumMünchen, Munich, Germany

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  • Holger Ludwig,

    Affiliation: Division of Virology, Paul-Ehrlich-Institut, Langen, Germany

    Current address: Meyer-Dulheuer & Partner, Frankfurt am Main, Germany.

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  • Stefan A. Paschen,

    Affiliation: Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany

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  • Andreas Villunger,

    Affiliation: Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Gerd Sutter,

    Affiliations: Division of Virology, Paul-Ehrlich-Institut, Langen, Germany, Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität, Munich, Germany

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  • Ingo Drexler,

    Affiliation: Institute of Virology and Clinical Cooperation Group “Antigen-specific Immunotherapy”, TechnischeUniversitätMünchen and Helmholtz ZentrumMünchen, Munich, Germany

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  • Georg Häcker mail

    georg.haecker@uniklinik-freiburg.de

    Affiliation: Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany

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  • Published: June 16, 2011
  • DOI: 10.1371/journal.ppat.1002083

About the Authors

Pedro Eitz Ferrer
Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany
Pedro Eitz Ferrer, Stephanie Potthoff, Susanne Kirschnek, Stefan A. Paschen, Georg Häcker
Institute of Medical Microbiology and Hygiene, University Freiburg, Freiburg, Germany
Pedro Eitz Ferrer
University of Freiburg, Faculty of Biology, Freiburg, Germany
Georg Gasteiger, Wolfgang Kastenmüller, Ingo Drexler
Institute of Virology and Clinical Cooperation Group “Antigen-specific Immunotherapy”, TechnischeUniversitätMünchen and Helmholtz ZentrumMünchen, Munich, Germany
Holger Ludwig, Gerd Sutter
Division of Virology, Paul-Ehrlich-Institut, Langen, Germany
Andreas Villunger
Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
Gerd Sutter
Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität, Munich, Germany

Corresponding Author

Email: georg.haecker@uniklinik-freiburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PEF SP SK GG HL WK SAP AV GS ID GH. Performed the experiments: PE SP GG WK. Analyzed the data: PEF GG WK. Contributed reagents/materials/analysis tools: SK HL WK SAP AV GS ID GH. Wrote the paper: PEF AV GS ID GH.