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Research Article

HIV-1 Efficient Entry in Inner Foreskin Is Mediated by Elevated CCL5/RANTES that Recruits T Cells and Fuels Conjugate Formation with Langerhans Cells

  • Zhicheng Zhou,

    Affiliations: Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France, INSERM, U1016, Paris, France, Université Paris Descartes, Paris, France

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  • Nicolas Barry de Longchamps,

    Affiliations: Université Paris Descartes, Paris, France, Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France

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  • Alain Schmitt,

    Affiliations: INSERM, U1016, Paris, France, Université Paris Descartes, Paris, France, Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France

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  • Marc Zerbib,

    Affiliations: Université Paris Descartes, Paris, France, Urology Service, GH Cochin-St Vincent de Paul, Paris, France

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  • Marie-Cécile Vacher-Lavenu,

    Affiliations: Université Paris Descartes, Paris, France, Department of Pathology, GH Cochin-St Vincent de Paul, Paris, France

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  • Morgane Bomsel mail,

    morgane.bomsel@inserm.fr

    Affiliations: Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France, INSERM, U1016, Paris, France, Université Paris Descartes, Paris, France

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  • Yonatan Ganor

    Affiliations: Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France, INSERM, U1016, Paris, France, Université Paris Descartes, Paris, France

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.ppat.1002100

About the Authors

Zhicheng Zhou, Morgane Bomsel, Yonatan Ganor
Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France
Zhicheng Zhou, Alain Schmitt, Morgane Bomsel, Yonatan Ganor
INSERM, U1016, Paris, France
Zhicheng Zhou, Nicolas Barry de Longchamps, Alain Schmitt, Marc Zerbib, Marie-Cécile Vacher-Lavenu, Morgane Bomsel, Yonatan Ganor
Université Paris Descartes, Paris, France
Nicolas Barry de Longchamps, Alain Schmitt
Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France
Marc Zerbib
Urology Service, GH Cochin-St Vincent de Paul, Paris, France
Marie-Cécile Vacher-Lavenu
Department of Pathology, GH Cochin-St Vincent de Paul, Paris, France

Corresponding Author

Email: morgane.bomsel@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YG ZZ MB. Performed the experiments: YG MB ZZ AS. Analyzed the data: MB YG ZZ. Contributed reagents/materials/analysis tools: NBDL MZ MCVL. Wrote the paper: YG MB.