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Research Article

Contribution of Intrinsic Reactivity of the HIV-1 Envelope Glycoproteins to CD4-Independent Infection and Global Inhibitor Sensitivity

  • Hillel Haim,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Bettina Strack,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Aemro Kassa,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Navid Madani,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Liping Wang,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Joel R. Courter,

    Affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Amy Princiotto,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Kathleen McGee,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Beatriz Pacheco,

    Affiliation: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michael S. Seaman,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Amos B. Smith III,

    Affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Joseph Sodroski mail

    joseph_sodroski@dfci.harvard.edu

    Affiliations: Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, Unites States of America

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  • Published: June 23, 2011
  • DOI: 10.1371/journal.ppat.1002101

About the Authors

Hillel Haim, Bettina Strack, Aemro Kassa, Navid Madani, Liping Wang, Amy Princiotto, Kathleen McGee, Beatriz Pacheco, Joseph Sodroski
Department of Cancer Immunology and AIDS, Dana–Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
Joel R. Courter, Amos B. Smith III
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Michael S. Seaman
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
Joseph Sodroski
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, Unites States of America

Corresponding Author

Email: joseph_sodroski@dfci.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HH BS JS. Performed the experiments: HH BS BP. Analyzed the data: HH BS AK JS. Contributed reagents/materials/analysis tools: NM LW JRC AP KM MSS ABS. Wrote the paper: HH JS.