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Research Article

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

  • Ioan Iacovache equal contributor,

    equal contributor Contributed equally to this work with: Ioan Iacovache, Matteo T. Degiacomi

    Affiliation: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Matteo T. Degiacomi equal contributor,

    equal contributor Contributed equally to this work with: Ioan Iacovache, Matteo T. Degiacomi

    Affiliation: Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Lucile Pernot,

    Affiliation: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Current address: Pharmaceutical Biochemistry Group, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland

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  • Sylvia Ho,

    Affiliation: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Marc Schiltz,

    Affiliation: Laboratoire de Cristallographie, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Matteo Dal Peraro mail,

    gisou.vandergoot@epfl.ch (FGVDH); matteo.dalperaro@epfl.ch (MDP)

    Affiliation: Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • F. Gisou van der Goot mail

    gisou.vandergoot@epfl.ch (FGVDH); matteo.dalperaro@epfl.ch (MDP)

    Affiliation: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Published: July 14, 2011
  • DOI: 10.1371/journal.ppat.1002135

About the Authors

Ioan Iacovache, Lucile Pernot, Sylvia Ho, F. Gisou van der Goot
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Matteo T. Degiacomi, Matteo Dal Peraro
Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Marc Schiltz
Laboratoire de Cristallographie, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: II MTD LP MDP FGVDG. Performed the experiments: II MTD LP SH. Analyzed the data: II MTD LP MDP FGVDG MS. Contributed reagents/materials/analysis tools: II MTD LP MDP FGVDG. Wrote the paper: II MTD LP MDP FGVDG SH.