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Research Article

Thy1+ Nk Cells from Vaccinia Virus-Primed Mice Confer Protection against Vaccinia Virus Challenge in the Absence of Adaptive Lymphocytes

  • Geoffrey O. Gillard,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Maytal Bivas-Benita,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Avi-Hai Hovav,

    Affiliations: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Institute of Dental Sciences, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

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  • Lauren E. Grandpre,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michael W. Panas,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michael S. Seaman,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Barton F. Haynes,

    Affiliation: Duke University School of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Norman L. Letvin mail

    nletvin@bidmc.harvard.edu

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.ppat.1002141

About the Authors

Geoffrey O. Gillard, Maytal Bivas-Benita, Avi-Hai Hovav, Lauren E. Grandpre, Michael W. Panas, Michael S. Seaman, Norman L. Letvin
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Avi-Hai Hovav
Institute of Dental Sciences, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel
Barton F. Haynes
Duke University School of Medicine, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: nletvin@bidmc.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GOG NLL. Performed the experiments: GOG MBB LEG MWP. Analyzed the data: GOG AHH MSS BFH NLL. Contributed reagents/materials/analysis tools: MSS. Wrote the paper: GOG.