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Research Article

Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus

  • Jie Sun,

    Affiliation: The Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America

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  • Amber Cardani,

    Affiliation: The Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America

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  • Ashish K. Sharma,

    Affiliation: Department of Surgery, The University of Virginia, Charlottesville, Virginia, United States of America

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  • Victor E. Laubach,

    Affiliation: Department of Surgery, The University of Virginia, Charlottesville, Virginia, United States of America

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  • Robert S. Jack,

    Affiliation: Department of Immunology, University of Greifswald, Germany

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  • Werner Müller,

    Affiliation: Bill Ford Chair of Cellular Immunology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Thomas J. Braciale mail

    tjb2r@virginia.edu

    Affiliations: The Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America, Department of Microbiology, The University of Virginia, Charlottesville, Virginia, United States of America, Department of Pathology, The University of Virginia, Charlottesville, Virginia, United States of America

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.ppat.1002173

About the Authors

Jie Sun, Amber Cardani, Thomas J. Braciale
The Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
Ashish K. Sharma, Victor E. Laubach
Department of Surgery, The University of Virginia, Charlottesville, Virginia, United States of America
Robert S. Jack
Department of Immunology, University of Greifswald, Germany
Werner Müller
Bill Ford Chair of Cellular Immunology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Thomas J. Braciale
Department of Microbiology, The University of Virginia, Charlottesville, Virginia, United States of America
Thomas J. Braciale
Department of Pathology, The University of Virginia, Charlottesville, Virginia, United States of America

Corresponding Author

Email: tjb2r@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS TJB. Performed the experiments: JS AC AKS. Analyzed the data: JS VEL TJB. Contributed reagents/materials/analysis tools: RSJ WM. Wrote the paper: JS TJB.